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Replacements: 16 William Servat, 17 Yohan Montes, 18 Johnson Falefa, 19 Romain Millo Chluski, 20 Jean Marc Doussain, 21 Yves Donguy, 22 Yann David , 23 Shaun Sowerby
BenchmarkQuins director of rugby Conor O'Shea is full of respect for Toulouse.
The backline shows one change with Benjamin Urdapilleta taking over at inside centre from Tom Casson who picked up an ankle injury in training.
George Robson bolsters to the front five alongside Tomas Vallejos, with the hooker rotation between Chris Brooker and Joe Gray continuing. Brooker will take over in the starting XV in between Joe Marler and James Johnston.
where we stand, and we are playing against the best side in Europe."
Nick Easter is back at number eight, allowing captain Chris Robshaw to return to the flank, partnered with Maurie Fa'asavalu.
Toulouse's starting line up features no less than 13 internationals, only Fijian wing Timoci Matanavou who has scored six tries this season and lock Yoann Maestri do not have Test caps.
"It is why we want to be in the Heineken Cup to play against teams like Converse Dainty Grey Size 6
Harlequins: 15 Mike Brown, 14 Seb Stegmann, 13 Matt Hopper, 12 Benjamin Urdapilleta, 11 Sam Smith, 10 Nick Evans, 9 Danny Care, 8 Nick Easter, 7 Chris Robshaw, 6 Maurie Fa'asavalu, Converse White Shoes Low Cut
Toulouse: 15 Maxime Medard, 14 Vincent Clerc, 13 Florian Fritz, 12 Yannick Jauzion, 11 Timoci Matanavou, 10 Luke McAlister, 9 Luke Burgess, 8 Louis Picamoles, 7 Thierry Dusautoir, 6 Yannick Nyanga, 5 Yoann Maestri, 4 Gr gory Lamboley, 3 Census Johnston, 2 Gary Botha, 1 Jean Baptiste Poux.
Harlequins v Toulouse
Former Bulls hooker Gary Botha starts ahead of William Servat, who is on the bench, and former All Black Luke McAlister leads the attack alongside former Wallaby Luke Burgess for the Top 14 Converse Wedding Shoes pacesetters.
The Aviva Premiership leaders head back into European mode off the back of two domestic victories that stretched their winning streak to 14 matches.
Replacements: 16 Joe Gray, 17 Mark Lambert, 18 Kyle Sinckler, 19 Charlie Matthews, 20 Luke Wallace, 21 Richard Bolt, 22 Rory Clegg, 23 Ugo Monye
The last time these teams met in the Heineken Cup was back in the 2009/10 season. Guy Noves' men completed the double of Quins in that season, winning 23 19 at the Stoop and 33 21 at Stade Ernest Wallon.
ChangesHarlequins' line up sees a number of players return after missed the victory over London Wasps last weekend.
But something has to give when the French giants visit London as both teams have won their opening two fixtures in Pool Six, one victory each over both Gloucester and Connacht.
"They set the benchmark for European rugby," he said.
5 George Robson, 4 Tomas Vallejos, 3 James Johnston, 2 Chris Brooker, 1 Joe Marler
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